Institute of Microelectronics of Barcelona (IMB-CNM)
Integrated Micro and Nanofabrication Clean Room
OneWeb ends its 5th launch into space equipped with photodiodes of our Clean Room
An international project to improve reliability for electronic components
Welcome to the Institute of Microelectronics of Barcelona IMB-CNM-CSIC
The Barcelona Institute of Microelectronics (IMB-CNM), CSIC, is a well-positioned research center in the development of new Micro, Nano Technologies, Components and Systems. This center is a leader in the application of such technologies to solve social challenges and is aligned with the sustainable development objectives.
IMB-CNM research focuses on basic and applied research and development in micro and nanotechnologies, components and systems. Its lines of research include the entire value chain from the components of detection, power, and actuation, signal transmission and its application to the health and well-being of people, help control environmental conditions, and save and improve efficient management of energy.
A work published in ACS Nano shows a method that will allow to study the near-surface thermal and compositional properties of self-assembled block copolymers and thereby reveal their intrinsic driving forces, contributing to the progress of bottom-up manufacturing.
The device is the result of KardiaTool, a European project. It contains a biosensor chip developed in the Clean Room of the IMB-CNM, and functionalized magnetic nanoparticles synthesized at ICMAB, key to detect the biomarkers found in saliva.
The remarkable advances in molecular logic reported in the last decade demonstrate the potential of luminescent molecules for logical operations, a paradigm-changing concerning silicon-based electronics. Trivalent lanthanide (Ln3+) ions, with their characteristic narrow line emissions, long-lived excited states, and photostability under illumination, may improve the state-of-the-art molecular logical devices. Here, the use of monolithic silicon-based structures incorporating Ln3+ complexes for performing logical functions is reported. Contrary to chemical inputs, physical inputs may enable the future concatenation of distinct logical functions and reuse of the logical devices, a clear step forward toward input–output homogeneity that is precluding the integration of nowadays molecular logic devices.
Adv. Optical Mater. 2020, 2000312.
Here, we propose the integration of silicon nanowires on cell internalizable chips in order to combine the functional features of both approaches. The cellular uptake in HeLa cells of silicon 3 µm × 3 µm nanowire-based chips, and the results were compared with those of non-nanostructured silicon chips. Chip internalization without affecting cell viability was achieved however, important cell behavior differences were observed. The first stage of cell internalization was favored by silicon nanowire interfaces with respect to bulk silicon. In addition, chips were found inside membrane vesicles, and some nanowires seemed to penetrate the cytosol, which opens the door to the development of silicon nanowire chips as future intracellular sensors and drug delivery systems.
Nanomaterials 2020, 10(5), 893
We identify a program of forces and changes to the cytoplasmic mechanical properties required for mouse embryo development from fertilization to the first cell division. Injected, fully internalized chips responded to sperm decondensation and recondensation, and subsequent device behavior suggested a model for pronuclear convergence based on a gradient of effective cytoplasmic stiffness. The nanodevices reported reduced cytoplasmic mechanical activity during chromosome alignment and indicated that cytoplasmic stiffening occurred during embryo elongation, followed by rapid cytoplasmic softening during cell division. Forces greater than those inside muscle cells were detected. These results suggest that intracellular forces are part of a concerted program that is necessary for development at the origin of a new embryonic life.
Nat. Mater. (2020)